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Volume 4, Issue 1

Impact of radiotherapy on rectal goblet cells

www.doi.org/10.52768/jjgastro/1178

We investigated if irreversible radiation damage to the rectum directly impacts goblet cells and if this could impart explain the pathophysiology of radiation proctitis. We conducted a single institution retrospective review identifying two patient cohorts with rectal and anal cancers (T1-4N0-1M0).

Association between number of Barrett's esophagus risk factors and disease prevalence

www.doi.org/10.52768/jjgastro/1180

Current clinical practice guidelines recommend screening endoscopy for patients with multiple Barrett's Esophagus (BE) risk factors. However, there is only indirect evidence that BE risk factors are additive. We aimed to investigate the association between BE risk factors and BE prevalence in patients with GERD.

Influence of protein intake on clinical and nutritional parameters in pancreatic cancer

www.doi.org/10.52768/jjgastro/1181

Nutritional status is an important determinant of survival in patients with advanced pancreatic cancer. However, the effects of protein intake on nutritional status are largely unknown. This analysis examined the influence of guideline-consistent protein intake over 13 weeks on clinical outcomes (survival, adverse events, modification of chemotherapy regimes) and nutritional status.

Secondary biliary cirrhosis caused by cyproterone acetate

www.doi.org/10.52768/jjgastro/1182

Cyproterone acetate (CPA) is an oral anti-androgen commonly used to treat advanced prostate cancer. A variety of hepatotoxic reactions has been reported with CPA. The aim of this report is to describe a well-documented case of pateints treated with CPA and developing jaundice with a persistant anicteric cholestasis.